Product Details

Naturally gluten-free.

Ambrotose products are Mannatech’s foundational glyconutritional dietary supplements, with nine patents issued, granted, and validated in major global markets for the Ambrotose formulation.

Ten studies have been published in peer-reviewed journals about Ambrotose powders.  Eight of these studies were human clinical trials, six of which were gold-standard, randomized placebo-controlled clinical trials. These studies indicate that Ambrotose powders can:

  • Support cellular communication*
  • Are the first dietary supplements shown to impact the N-glycosylation profile of human serum glycoproteins*
  • Are safe and natural daily supplements for year-round immune system support*
  • Can enhance the body’s response to vaccinations*
  • Enhance memory and mood*
  • Help promote gastrointestinal health*
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Ingredients

Functional

  • Aloe vera extract (inner leaf gel powder)

     Aloe vera extract inner leaf gel powder includes Manapol®, a polysaccharide found in aloe vera gel. A unique ingredient exclusive to Mannatech, Incorporated, Manapol is extracted from fresh, washed and filtered gel by a specialized extraction method that yields insoluble fibers and stabilized, high molecular weight (MW) soluble fibers rich in long-chain mannose sugars—beta-(1-4)-acetylated polymannans. Many attribute the benefits of topically and orally-applied aloe vera gel to its polymannan content. The MW of over 20% of Manapol is >800,000. It also contains the monosaccharide sugars glucuronic acid, glucose, galacturonic acid, xylose, galactose, glucosamine, fucose, rhamnose and arabinose, and small amounts of protein, calcium, potassium and sulfate 1,2,3.

    Expand References

    References

    1. Luta G, McAnalley B. Aloe vera: chemical composition and methods used to determine its presence in commercial products. GlycoScience & Nutrition 2005;6:1-12.
    2. Duncan, C., Ramberg, J., and Sinnott, R. Striking differences in Aloe vera gel carbohydrate composition, molecular weight and particle size distributions following processing will not be addressed by dietary supplement GMPs. Poster Presentation at the 5th Annual Natural Supplements Conference, January 17-20, 2008, Scripps Center for Integrative Medicine, San Diego, California.
    3. Luta G, Duncan C, Sinnott R. Chemical characterization of polysaccharide-rich ingredients from Aloe vera, Larix laricina and Larix occidentalis, and Undaria pinnatifida. Presented at the 6th Annual Natural Supplements Conference, January 22-25, 2009, Scripps Center for Integrative Medicine, San Diego, California.
  • Arabinogalactan (from Larix spp. wood)

    Arabinogalactans are a class of long, densely branched high-molecular weight polysaccharides extracted for commercial uses from the bark of the Eastern and Western Larch trees, Larix larcinia and Larix occidentalis. Their monosaccharide constituents include galactose, arabinose, glucose and mannose 1. Larch arabinogalactans are considered a good source of prebiotic soluble dietary fiber 2,3. Small amounts of arabinogalactans can be found in some food plants, including corn, carrots, tomatoes, pears, wheat and red wine 4.

    A human double-blind, placebo-controlled trial indicates that intake of 1.5 grams of a larch arabinogalactan can enhance the antigenic response to a bacterial (tetanus) and viral (flu) challenges in healthy subjects 5. Both Ambrotose powders provide > 1.5 grams of this larch arabinogalactan/day.  Two human double-blind, placebo-controlled trials indicated that higher doses of  this arabinogalactan (4.5 grams) can enhance the response to a bacterial (pneumococcal) challenge 6,7.

    Larch arabinogalactans are approved by the U.S. Food and Drug Administration (FDA) as generally recognized as safe (GRAS) (21CFR172.610).

    Expand References

    References

    1. Luta G, Duncan C, Sinnott R. Chemical characterization of polysaccharide-rich ingredients from Aloe vera, Larix laricina and Larix occidentalis, and Undaria pinnatifida. Presented at the Scripps Center for Integrative Medicine's 6th Annual Natural Supplements Conference, San Diego, California.January 22-25, 2009. 2009.
    2. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    3. Kelly GS. 'Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern.Med Rev 1999;4:96-103.
    4. Cui SW. Polysaccharide Gums from Agricultural Products: Processing, Structures & Functionality. Lancaster, Pa.: Technomic Publishing Co., Inc., 2001.
    5. Udani JK. Immunomodulatory effects of ResistAid: A randomized, double-blind, placebo-controlled, multidose study. J Am Coll Nutr 2013;32:331-8.
    6. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:1-7.
    7. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory infections. Curr Med Res Opin 2013;29:251-8.
  • Ghatti gum

    Ghatti gum, a mixture of complex polysaccharides, comes from the bark of Anogeissus latifolia, a large tree native to India and Sri Lanka. Monosaccharide constituents include arabinose, galactose, mannose, xylose and glucuronic acid. Ghatti gum is used in supplements, foods, drugs and cosmetics. It contains as much as 80% soluble dietary fiber 1.

    Most gums are believed to be largely degraded in the colon 2. Test tube studies have demonstrated the fermentation of ghatti gum by the beneficial human bacteria species Bifidobacterium 3,4. Ghatti gum is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and is permitted for use as a food (21CFR184.1333).

    Expand References

    References

    1. Glicksman M. Gum Ghatti (Indian gum). In: Glicksman M, ed. Food Hydrocolloids. Boca Raton: CRC Press 1983:31-7.
    2. Hill MJ. Bacterial fermentation of complex carbohydrate in the human colon. Eur J Cancer Prev 1995;4:353-8.
    3. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    4. Salyers AA, West SE, Vercellotti JR, Wilkins TD. Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon. Appl Environ Microbiol 1977;34:529-33.
  • Glucosamine HCl

    Glucosamine HCl is a salt of the amino monosaccharide, glucosamine, which is used to adjust the pH (the acidity or alkalinity) of cosmetics and personal care products 1.

    Expand References

    References

    1. International Cosmetic Ingredient Dictionary and Handbook. Washington, D.C.: The Cosmetic, Toiletry and Fragrance Association, 2006.
  • Gum tragacanth

    Gum tragacanth comes from the stems and branches of the flowering plant Astragalus gummifer. The raw gum is made up of a mixture of two polysaccharides. Monosaccharide constituents include galactose, arabinose, xylose, fucose, rhamnose, and galacturonic acid 1. Gum tragacanth has been approved for use in pharmaceuticals in the U.S. since 1820 and in foods since 1925 2. Most gums are believed to be largely degraded in the colon 3. Test tube studies have demonstrated that gum tragacanth can be digested by a number of bacteria that inhabit the human colon, including the beneficial Bifidobacteria species 4,5. Gum tragacanth is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and is commonly added to foods (21CFR184.1351).

    Expand References

    References

    1. Anderson DM, Howlett JF, McNab CG. The amino acid composition of the proteinaceous component of gum tragacanth (Asiatic Astragalus spp.). Food Addit Contam 1985;2:231-5.
    2. Anderson DM. Evidence for the safety of gum tragacanth (Asiatic Astragalus spp.) and modern criteria for the evaluation of food additives. Food Addit Contam 1989;6:1-12.
    3. Hill MJ. Bacterial fermentation of complex carbohydrate in the human colon. Eur J Cancer Prev 1995;4:353-8.
    4. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    5. Salyers AA, West SE, Vercellotti JR, Wilkins TD. Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon. Appl Environ Microbiol 1977;34:529-33.

Formulation

  • Rice starch

    Rice starch is a polysaccharide obtained from rice, Oryza sativa.  Worldwide, natural starch is an important source of energy. Humans and other animals have enzymes that are able to digest starch into its glucose components, so it can be easily digested. Rice starch is an approved food additive by the U.S. Food and Drug Administration (FDA) 1.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.

Product Claims

Products

Ambrotose Complex® Powder

Product Numbers

37101: 100 g Ambrotose Complex Powder

Country

South Africa

Effective

March 2017

Supersedes

October 2016
  • Quality and Safety
    • NSF-certified
    • Gluten-free
    • Naturally gluten-free
    • Low glycemic
    • No genetically modified DNA
    • Free from dairy, soy
    • No artificial flavors, artificial colors, MSG, preservatives
    • Contains naturally sourced ingredients
    • Non-irradiated
    • Patented formulation
  • Cellular Communication

    4 Grams/Day  Ambrotose Complex Powder


    • Supports cellular communication*
    • Intake of Ambrotose powders significantly modified the N-glycosylation profiles of serum glycoproteins*
    • Clinical studies have shown that Ambrotose powders can significantly modify the sugars attached to serum glycoproteins*
    • Ambrotose products are the first dietary supplements shown to impact the N-glycosylation profile of human serum glycoproteins*
    • Designed to support cellular communication, Ambrotose powders have been shown to affect serum protein glycosylation*
  • Immune System Benefits

    4 Grams/Day Ambrotose Complex Powder


    • Preliminary evidence suggests that superior immunologic benefits may be provided by the ingestion of higher molecular weight polysaccharides*
    • Rich in high molecular weight polysaccharides
    • Rich in polysaccharides >1.4 million daltons
    • Contains a standardized amount of high molecular weight acetylated mannans
    • Contains a standardized amount of acetylated mannans ≥1 million daltons
    • Includes a standardized amount of the very high molecular weight Acemannan polysaccharides (1-2 million daltons) as defined by the American Chemical Society
    • Ambrotose powders can [support, improve, bolster, enhance, activate] [the/your] body’s immune response to vaccinations against bacterial infections*
    • May help keep your immune system strong year*
    • Safe and natural daily supplement for year-round immune system-support*
      • Take [Ambrotose complex powder/Advanced Ambrotose powder] regularly for year round immune system support, especially during the winter months when our immune systems are particularly challenged*
    • Daily intake of Ambrotose powders may help keep your immune system strong year-round*
      • Take [Ambrotose complex powder/Advanced Ambrotose powder] regularly to help keep you healthy year-round*
    • Can enhance your body’s response to vaccinations*
      • Take [Ambrotose complex powder/Advanced Ambrotose powder] for about two months before your next vaccination to [bolster/improve/enhance] your immune system’s response*
      • Taking [Ambrotose complex powder/Advanced Ambrotose powder] regularly can [bolster/improve/enhance] your response to vaccinations*
    • [Stimulates/boosts/bolsters/enhances/activates] [your/the] immune system*
    • May [Support, improve, bolster, enhance/activate] [the/your] body’s ability to respond to pathogens*
    • [Supports, improves, bolsters, enhances, activates] [the/your] body’s ability to respond to bacterial vaccines*
    • Modulates and supports your body’s immune response*
    • Supports the innate immune response*
    • May improve the adaptive immune response*
    • Daily intake of Ambrotose powders can help keep your immune system strong year-round*
    • Taking Ambrotose powder daily can [stimulate/boost/bolster/enhance/activate] your immune system*
    • May improve overall wellness*
    • Supports [the/your] body’s natural immune response*
    • Supports healthy immune function*
    • Supports a healthy immune response*
    • Supports a healthy immune system*
    • Dietary polysaccharides in Ambrotose powders, including arabinogalactans, fucoidans and glucans, have been shown to have immunomodulatory activities in controlled studies with human subjects*
    • Dietary polysaccharides in Ambrotose powders have been shown to elicit immunomodulatory effects in controlled studies of human subjects*
    • Rich in plant polysaccharides that may support a healthy immune system*
    • In a clinical trial, intake of polysaccharides in Ambrotose powder was shown to support the body’s natural defenses to help people stay healthy*
    • Includes plant fibers for immune system health*
    • Studies suggest that dietary fiber supports a healthy immune system
    • Supports [the/your] body’s natural immune response*
    • Supports healthy immune function*
    • Supports a healthy immune response*
    • Supports a healthy immune system*
  • Cognitive Benefits

    4 grams/day Advanced Ambrotose and Ambrotose Complex Powders


    • In a small double-blind, placebo-controlled clinical trial, Ambrotose complex powder taken for 12 weeks significantly enhanced immediate recall and recognition memory in middle aged adults*
    • In a small double-blind, placebo-controlled clinical trial, Ambrotose complex powder taken for 12 weeks significantly improved mood and decreased irritability in middle aged adults*
    • In a double-blind, placebo-controlled clinical trial, Ambrotose powder significantly improved memory and mood*
    • In a double-blind, placebo-controlled clinical trial, Ambrotose powder significantly improved well-being*
    • In a double-blind, placebo-controlled clinical trial, Ambrotose powder significantly improved a positive outlook*
    • In double-blind, placebo-controlled clinical trials, Ambrotose powder significantly improved memory*
    • In a double-blind, placebo-controlled clinical trial subjects who took Ambrotose complex powder reported improved sleep, and increased calmness, concentration and clear-headedness*
    • May enhance recall and recognition memory*
    • May improve mood and decrease irritability*
    • Improves mood*
    • [Enhances/improves/boosts/supports] memory*
    • [Enhances/improves/boosts/supports] brain function*
    • [Enhances/improves/boosts/supports] cognitive function*
    • Improves perceived psychological well-being*
    • Improves well-being*
    • Improves perceived quality of-life*
    • May improve quality-of-life*
    • Prevents mental stress*
    • Mitigates cognitive fatigue*
    • May improve visual discrimination*
    • Helps support cognitive function*

  • Fiber

    4 Grams/Day  Ambrotose Complex Powder


    • A blend of plant-sourced polysaccharides
    • A source of dietary fiber
    • A source of soluble fiber
    • Ambrotose products contain complex polysaccharides (including arabinogalactan)
    • Adds to your daily fiber intake
  • Gastrointestinal/Prebiotic Benefits

    4 Grams/Day Ambrotose Complex Powder


    • Prebiotic dietary supplement
    • Supports the growth of good gut bacteria*
    • Supports the growth of good gut bacteria*
    • Helps promote gastrointestinal health*
    • Helps support proper digestive system function*
    • The complex polysaccharides in Ambrotose powders increase the number of beneficial bacterial in the gut*
    • Individual ingredients in Ambrotose powders demonstrate prebiotic effects. For example, arabinogalactan can be fermented by human colonic bacteria and enhance the growth of Lactobacillus species, including Lactobacillus plantarum*
    • Research indicates that the larch arabinogalactan in Ambrotose powders supports the proliferation of Lactobacillus plantarum, a beneficial bacteria found in the colon and lower GI tract*
    • The arabinogalactan in the Ambrotose powders may be broken down and utilized by specific bacteria found in the intestines, including Lactobacillus plantarum and Bifidobacterium longum
    • Research indicates that the larch arabinogalactan in Ambrotose powders supports the proliferation of beneficial bacteria found in the colon*
    • Research indicates that the larch arabinogalactan in Ambrotose powders supports the proliferation of Lactobacillus plantarum*
    • Ambrotose powders have been found to have a bifidogenic and lactobacillogenic effect, increasing the number of these beneficial bacteria*
    • In a state-of-the art in vitro model, Advanced Ambrotose significantly increased the number of beneficial bacteria (Bifidobacteria and Lactobacilli) in the colon*
    • Research using a state-of-the-art simulation of the human gastrointestinal tract showed that Ambrotose powders can increase the numbers of the beneficial bacteria Bifidobacteria, as well as species belonging to Bacteriodetes, a phylum recently associated with body weight management*
    • Ambrotose powders are effective prebiotic supplements, able to be [digested/fermented] by human colonic bacteria and promote the growth of beneficial bacteria*
    • In August 2007, Mannatech scientists published research in the International Journal of Probiotics and Prebiotics that showed naturally-occurring bacteria in the GI tract can digest Ambrotose ingredients into small fragments
  • About Prebiotics
    • GI tract bacteria, such as Lactobacilli and Bifidobacteria, are important for GI health*
    • GI tract bacteria decrease the growth of pathogenic bacteria and increase production of short chain fatty acids in the gut, both of which are believed to be positive for GI health. Lactobacilli and Bifidobacteria are bacteria known to be important for GI tract health*
    • Prebiotics are non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of beneficial bacteria in the colon, thereby supporting host health*
    • Currently identified prebiotics are oligosaccharides, which exert prebiotic effects in the promixal colon but are unlikely to exert prebiotic effects throughout the colon

     

     

  • About Glycosylation
    • Glycosylation is the enzymatic process that attaches sugars (glycans) to proteins, lipids, or other organic molecules. These attached sugars can be structural and/or functional. In their functional role, they serve as antennae, interacting with cellular receptors and thus affecting cellular processes
    • Sugars attached to proteins (glycoproteins) serve as signals in cellular communication, thus influencing processes involved in inflammation and immunological reactions*
    • Glycosylation is a key post-translational protein modification that can significantly affect the overall biophysical and biochemical functions of proteins
    • The function of glycoproteins is profoundly affected by their component sugars
    • Modifications of glycoproteins results in changes in their structure, with ensuing modulation of molecular and cellular signaling processes. Changes in signaling processes can result in changes in cellular interactions, including those involved in immunological and inflammatory processes*
    • Sialylation of glycoproteins affects their immunogenic properties, as well as absorption, half-life and clearance*
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