Product Details

Naturally gluten-free. Suitable for vegetarians.

Shown in human clinical trials to enhance cardiorespiratory fitness*

 

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Ingredients

Functional

  • Aloe vera (inner leaf gel powder)

    Aloe vera inner leaf gel powder  is the powder obtained from the freeze-dried gel from the leaves of the aloe vera plant, Aloe barbadensis.

    For centuries, the plant aloe vera has been used by cultures for its beneficial effects on human health 1. Today aloe vera gel continues to be used in supplements, foods, beverages, and cosmetics. Aloe leaves consist of two major parts, the outer leaf epidermis and the inner leaf gel, which are very different in their chemical composition and properties. Aloe gel is obtained from the inner portion of the leaves. Aloe gel is rich in nutrients and contains an abundant supply of glycoproteins and mono-, oligo- and polysaccharides. Monosaccharide constituents include glucose, mannose, galacturonic acid, glucuronic acid, galactose, arabinose, fucose, glucosamine, fructose, rhamnose and xylose 2.

    Much of the health benefits observed by the use of aloe vera gel may be attributed to its high molecular weight polysaccharides. Before a process was developed to stabilize aloe vera gel or extracts, fresh preparations were regarded as being required for any therapeutic efficacy 3. It has now been shown that careful drying of aloe vera gel can retain the polysaccharide content important for producing many of its health benefits 4.

    Expand References

    References

    1. The Merck Index. Whitehouse Station, NJ: Merck & Co., Inc., 1996.
    2. Duncan, C., Ramberg, J., and Sinnott, R. Striking differences in Aloe vera gel carbohydrate composition, molecular weight and particle size distributions following processing will not be addressed by dietary supplement GMPs. Poster Presentation at the 5th Annual Natural Supplements Conference, January 17-20, 2008, Scripps Center for Integrative Medicine, San Diego, California.
    3. Gjerstad G, Riner TD. Current status of aloe as a cure-all. Am J Pharm Sci Support Public Health 1968;140:58-64.
    4. Ni Y, Turner D, Yates KM, Tizard I. Isolation and characterization of structural components of Aloe vera L. leaf pulp. Int J Immunopharmacol. 2004;4:1745-55.
  • Arabinogalactan (from Larix spp. wood)

    Arabinogalactans are a class of long, densely branched high-molecular weight polysaccharides extracted for commercial uses from the bark of the Eastern and Western Larch trees, Larix larcinia and Larix occidentalis. Their monosaccharide constituents include galactose, arabinose, glucose and mannose 1. Larch arabinogalactans are considered a good source of prebiotic soluble dietary fiber 2,3. Small amounts of arabinogalactans can be found in some food plants, including corn, carrots, tomatoes, pears, wheat and red wine 4.

    A human double-blind, placebo-controlled trial indicates that intake of 1.5 grams of a larch arabinogalactan can enhance the antigenic response to a bacterial (tetanus) and viral (flu) challenges in healthy subjects 5. Both Ambrotose powders provide > 1.5 grams of this larch arabinogalactan/day.  Two human double-blind, placebo-controlled trials indicated that higher doses of  this arabinogalactan (4.5 grams) can enhance the response to a bacterial (pneumococcal) challenge 6,7.

    Larch arabinogalactans are approved by the U.S. Food and Drug Administration (FDA) as generally recognized as safe (GRAS) (21CFR172.610).

    Expand References

    References

    1. Luta G, Duncan C, Sinnott R. Chemical characterization of polysaccharide-rich ingredients from Aloe vera, Larix laricina and Larix occidentalis, and Undaria pinnatifida. Presented at the Scripps Center for Integrative Medicine's 6th Annual Natural Supplements Conference, San Diego, California.January 22-25, 2009. 2009.
    2. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    3. Kelly GS. 'Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern.Med Rev 1999;4:96-103.
    4. Cui SW. Polysaccharide Gums from Agricultural Products: Processing, Structures & Functionality. Lancaster, Pa.: Technomic Publishing Co., Inc., 2001.
    5. Udani JK. Immunomodulatory effects of ResistAid: A randomized, double-blind, placebo-controlled, multidose study. J Am Coll Nutr 2013;32:331-8.
    6. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:1-7.
    7. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory infections. Curr Med Res Opin 2013;29:251-8.
  • Calcium citrate

    Calcium citrate is the calcium salt of citric acid used as a source of the essential mineral calcium in dietary supplements. Calcium citrate is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) 1.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Choline bitartrate

    Choline is a nutrient related to the water-soluble B-complex vitamins that is necessary for the structure and function of all cells. It is important for the structural integrity of cell membranes and proper functioning of the brain, as well as required for a number of metabolic reactions that take place in the body. Humans can synthesize choline themselves, or they can consume choline through the diet. It can be found in high amounts in foods such as egg yolk, peanuts, fish, milk and a variety of meats and vegetables. Dietary choline is absorbed from the small intestine and travels through the bloodstream to all organs and tissues of the body. No adverse effects have been seen with choline intakes at the amounts present in our products 1.
    Choline bitartrate is a salt of the nutrient choline. It is commonly used as a source of choline in dietary supplements 2. Choline bitartrate is considered generally recognized as safe (GRAS) for human consumption by the U.S. Food and Drug Administration (FDA) (21CFR182.8250) 3.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press, 2000.
    2. PDR for Nutritional Supplements. Montvale, NJ: Physicians’ Desk Reference, Inc, 2008.
    3. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Fructose

    Fructose, also known as levulose, is a monosaccharide sugar that occurs naturally in honey and a number of fruits. It is used as a flavoring and sweetening agent in foods. Fructose is the sweetest sugar, sweeter than the other monosaccharide sugars glucose and sucrose 1. It is approved for use as a food additive by the U.S. Food and Drug Administration 2.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
    2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Ghatti gum

    Ghatti gum, a mixture of complex polysaccharides, comes from the bark of Anogeissus latifolia, a large tree native to India and Sri Lanka. Monosaccharide constituents include arabinose, galactose, mannose, xylose and glucuronic acid. Ghatti gum is used in supplements, foods, drugs and cosmetics. It contains as much as 80% soluble dietary fiber 1.

    Most gums are believed to be largely degraded in the colon 2. Test tube studies have demonstrated the fermentation of ghatti gum by the beneficial human bacteria species Bifidobacterium 3,4. Ghatti gum is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and is permitted for use as a food (21CFR184.1333).

    Expand References

    References

    1. Glicksman M. Gum Ghatti (Indian gum). In: Glicksman M, ed. Food Hydrocolloids. Boca Raton: CRC Press 1983:31-7.
    2. Hill MJ. Bacterial fermentation of complex carbohydrate in the human colon. Eur J Cancer Prev 1995;4:353-8.
    3. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    4. Salyers AA, West SE, Vercellotti JR, Wilkins TD. Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon. Appl Environ Microbiol 1977;34:529-33.
  • Gum tragacanth

    Gum tragacanth comes from the stems and branches of the flowering plant Astragalus gummifer. The raw gum is made up of a mixture of two polysaccharides. Monosaccharide constituents include galactose, arabinose, xylose, fucose, rhamnose, and galacturonic acid 1. Gum tragacanth has been approved for use in pharmaceuticals in the U.S. since 1820 and in foods since 1925 2. Most gums are believed to be largely degraded in the colon 3. Test tube studies have demonstrated that gum tragacanth can be digested by a number of bacteria that inhabit the human colon, including the beneficial Bifidobacteria species 4,5. Gum tragacanth is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and is commonly added to foods (21CFR184.1351).

    Expand References

    References

    1. Anderson DM, Howlett JF, McNab CG. The amino acid composition of the proteinaceous component of gum tragacanth (Asiatic Astragalus spp.). Food Addit Contam 1985;2:231-5.
    2. Anderson DM. Evidence for the safety of gum tragacanth (Asiatic Astragalus spp.) and modern criteria for the evaluation of food additives. Food Addit Contam 1989;6:1-12.
    3. Hill MJ. Bacterial fermentation of complex carbohydrate in the human colon. Eur J Cancer Prev 1995;4:353-8.
    4. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    5. Salyers AA, West SE, Vercellotti JR, Wilkins TD. Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon. Appl Environ Microbiol 1977;34:529-33.
  • L-carnitine

    L-carnitine is an amino acid derivative found in almost all cells of the human body where it is involved in the production of adenosine triphosphate (ATP), a form of biological energy. L-carnitine can be synthesized in the liver and kidneys from the essential amino acids L-lysine and L-methionine 1. It can also be consumed in foods of animal origin, such as lamb or beef, or as a dietary supplement. L-carnitine is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) 2.

    Expand References

    References

    1. PDR for Nutritional Supplements. Montvale, NJ: Physicians’ Desk Reference, Inc, 2008.
    2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Magnesium aspartate

    Magnesium aspartate is the magnesium salt of aspartic acid. It is used as a source of the essential mineral magnesium in dietary supplements.

    This ingredient can also be found in the following products:

  • Magnesium succinate

    Magnesium succinate is the magnesium salt of succinic acid used as a source of the essential mineral magnesium in dietary supplements.

    This ingredient can also be found in the following products:

  • Medium chain triglycerides

    Medium chain triglycerides (MCTs) are medium-chain fatty acid esters of glycerol. For commercial purposes, MCTs are derived from coconut or palm kernel oils. Once ingested, they are rapidly absorbed from the small intestine and then transported to the liver where they are broken down to produce energy for the body 1. MCTs are used as dietary supplements as well as formulation ingredients, acting as fillers or lubricants, to stabilize mixtures and to aid in absorption 2. MCTs are likely safe when used orally and appropriately 3.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. PDR for Nutritional Supplements. Montvale, NJ: Physicians’ Desk Reference, Inc, 2008.
    2. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
    3. Natural Medicines. Comprehensive Database. Therapeutic Research Faculty, 2003.
  • Potassium aspartate

    Potassium aspartate is the potassium salt of aspartic acid used as a source of potassium in dietary supplements.

    This ingredient can also be found in the following products:

  • Potassium succinate

    Potassium succinate is the potassium salt of succinic acid. It is used as a source of potassium in dietary supplements.

    This ingredient can also be found in the following products:

Formulation

  • Citric acid

    Citric acid occurs naturally in a number of plant species, including lemons and pineapples. It is also found naturally in the human body, mainly in the bones. In food products, citric acid is used as a flavor enhancer for its tart, acidic taste. As an excipient, it is used primarily to adjust the pH (the acidity or alkalinity) of a product 1. It is also used in skin care products for fragrance 2. Citric acid is considered generally recognized as safe (GRAS) and is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) 3. It is also included in the U.S. FDA Inactive Ingredients Guide as safe to use in the amounts present in our products 4.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
    2. International Cosmetic Ingredient Dictionary and Handbook. Washington, D.C.: The Cosmetic, Toiletry and Fragrance Association, 2006.
    3. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
    4. FDA Inactive Ingredients Guide. http://www.accessdata.fda.gov/scripts/cder/iig/index.cfm. 2007.
  • Modified food starch

    Modified food starch refers to a type of food starch (i.e. corn, wheat, rice, potato or tapioca) that is modified by treatment with certain acids, enzymes or compounds that bleach or alter its chemical properties. It is used to thicken, to improve texture and to maintain the water content of foods. Modified food starch is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) (21CFR172.892) 1.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Natural flavor(s)

    Natural flavors are oils or extracts containing the flavoring constituents derived from a variety of sources. The natural flavors in Mannatech’s products may be derived from spices, fruits or fruit juices, vegetables or vegetable juices, herbs, bark, buds, roots, leaves or similar plant materials, or dairy products. The significant function of such ingredients in foods or supplements is for flavor rather than nutrition (21CFR501.22).

  • Silicon dioxide

    Silicon dioxide, also known as silica, is added to capsule and tablet formulations to reduce clumping 1. Silica is found in many foods, particularly whole grains (oats and barley), sugar beets, sugar cane, soybeans, turnips, green beans 2. The average intake of silica in adults is 14-21 mg/day 3. The bioavailability of silicate additives is low 4. Silica that occurs in food and water has not been shown to cause any adverse effects 3.

    Expand References

    References

    1. The Merck Index. Whitehouse Station, NJ: Merck & Co., 2006.
    2. Nutritional Biochemistry and Metabolism. New York, New York: Elsevier, 1991.
    3. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.
    4. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, D.C.: National Academy Press, 2002.
  • Soy lecithin

    Soy lecithin is a combination of naturally occurring phospholipids extracted during the processing of soybean oil. It consists of three types of phospholipids- phosphatidylcholine, phosphatidylethanolamine and phosphotidylinositol. Soy lecithin is used commercially in substances as a natural way to stabilize liquid mixtures. Lecithin is approved by the U.S. Food and Drug Administration (FDA) for human consumption with the status generally recognized as safe (GRAS) (21CFR184.1400).

Publications

  • EMPACT™ Sports Drink Double-Blind, Placebo-Controlled Clinical Trial (2010)

    Dr. Allyn Byars (Angelo State University, San Angelo, TX), Dr. Susan Keith (Angelo State University) and their colleagues showed that a single serving of creatine-free EM•PACT sports drink significantly improved subjects’ maximal oxygen consumption (VO2max), time to exhaustion and percentage estimated non-protein fat substrate utilization [1]. Study was at least partially funded by Mannatech.

    Byars A, Keith S, Simpson W, et al. (2010) The influence of a pre-exercise sports drink (PRX) on factors related to maximal aerobic performance. J Int Soc Sports Nutr 7:1-6.
    This article can also be accessed from PubMed.
  • EMPACT™ Sports Drink Double-Blind, Placebo-Controlled Clinical Trial (2007)

    Dr. Allyn Byars, Kelly D. Schneider, Mandy C. Hesseltine (Angelo State University ), Dr. Warren K. Simpson (Hardin-Simmons University, Abilene, TX), and Dr. Mike Greenwood (Baylor University, Waco, TX) EM-PACT consumed prior to exercise, enhanced aerobic performance compared to the nation’s leading sports drink in healthy subjects.* Study was at least partially funded by Mannatech.

    Byars A, Schneider KD, Hesseltine MC, et al. (2007) Sports nutrition: comparing two sports drinks on aerobic performance. Appl Res Coach Athletics Ann 22:226-240.
  • EMPACT™ Sports Drink Double-Blind, Placebo-Controlled Clinical Trial (2006)

    Dr. Allyn Byars (Angelo State University, San Angelo, TX), Drs. Mike and Lori Greenwood (Baylor University, Waco, TX) and Dr. Warren K. Simpson (Hardin-Simmons University, Abilene, TX) showed that, when consumed by healthy subjects instead of water prior to exercise, EMPACT™ sports drink enhanced indices of cardiorespiratory fitness (specifically VO2max and time to exhaustion).* Study was at least partially funded by Mannatech.

    Byars A, Greenwood MGL (2006) The effectiveness of a pre-exercise performance drink (PRX) on indices of maximal cardiorespiratory fitness. J Int Soc Sports Nutr 3: 56-59.
    This article can also be accessed from PubMed.
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