Product Details

Naturally gluten-free.

MannaCLEANSE Caplets are designed to help support the body’s lower digestive tract by supporting the natural ecology of the intestines.*

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Ingredients

Functional

  • Aloe vera (inner leaf gel powder)

    Aloe vera inner leaf gel powder  is the powder obtained from the freeze-dried gel from the leaves of the aloe vera plant, Aloe barbadensis.

    For centuries, the plant aloe vera has been used by cultures for its beneficial effects on human health 1. Today aloe vera gel continues to be used in supplements, foods, beverages, and cosmetics. Aloe leaves consist of two major parts, the outer leaf epidermis and the inner leaf gel, which are very different in their chemical composition and properties. Aloe gel is obtained from the inner portion of the leaves. Aloe gel is rich in nutrients and contains an abundant supply of glycoproteins and mono-, oligo- and polysaccharides. Monosaccharide constituents include glucose, mannose, galacturonic acid, glucuronic acid, galactose, arabinose, fucose, glucosamine, fructose, rhamnose and xylose 2.

    Much of the health benefits observed by the use of aloe vera gel may be attributed to its high molecular weight polysaccharides. Before a process was developed to stabilize aloe vera gel or extracts, fresh preparations were regarded as being required for any therapeutic efficacy 3. It has now been shown that careful drying of aloe vera gel can retain the polysaccharide content important for producing many of its health benefits 4.

    Expand References

    References

    1. The Merck Index. Whitehouse Station, NJ: Merck & Co., Inc., 1996.
    2. Duncan, C., Ramberg, J., and Sinnott, R. Striking differences in Aloe vera gel carbohydrate composition, molecular weight and particle size distributions following processing will not be addressed by dietary supplement GMPs. Poster Presentation at the 5th Annual Natural Supplements Conference, January 17-20, 2008, Scripps Center for Integrative Medicine, San Diego, California.
    3. Gjerstad G, Riner TD. Current status of aloe as a cure-all. Am J Pharm Sci Support Public Health 1968;140:58-64.
    4. Ni Y, Turner D, Yates KM, Tizard I. Isolation and characterization of structural components of Aloe vera L. leaf pulp. Int J Immunopharmacol. 2004;4:1745-55.
  • Amylase

    Amylase is an enzyme produced by the salivary glands and the pancreas that can break down starch, glycogen and related polysaccharides into simple sugars 1. Amylase derived from widely utilized fungi and bacteria, such as Aspergillus niger and Bacillus subtilis, is approved for use as a food enzyme by the U.S. Food and Drug Administration (FDA) 2.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Ensminger AH, Ensminger ME, Konlande JE, Robson JRK. The Concise Encyclopedia of Foods and Nutrition. Boca Raton, Florida: CRC Press, 1995.
    2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Arabinogalactan (from Larix spp. wood)

    Arabinogalactans are a class of long, densely branched high-molecular weight polysaccharides extracted for commercial uses from the bark of the Eastern and Western Larch trees, Larix larcinia and Larix occidentalis. Their monosaccharide constituents include galactose, arabinose, glucose and mannose 1. Larch arabinogalactans are considered a good source of prebiotic soluble dietary fiber 2,3. Small amounts of arabinogalactans can be found in some food plants, including corn, carrots, tomatoes, pears, wheat and red wine 4.

    A human double-blind, placebo-controlled trial indicates that intake of 1.5 grams of a larch arabinogalactan can enhance the antigenic response to a bacterial (tetanus) and viral (flu) challenges in healthy subjects 5. Both Ambrotose powders provide > 1.5 grams of this larch arabinogalactan/day.  Two human double-blind, placebo-controlled trials indicated that higher doses of  this arabinogalactan (4.5 grams) can enhance the response to a bacterial (pneumococcal) challenge 6,7.

    Larch arabinogalactans are approved by the U.S. Food and Drug Administration (FDA) as generally recognized as safe (GRAS) (21CFR172.610).

    Expand References

    References

    1. Luta G, Duncan C, Sinnott R. Chemical characterization of polysaccharide-rich ingredients from Aloe vera, Larix laricina and Larix occidentalis, and Undaria pinnatifida. Presented at the Scripps Center for Integrative Medicine's 6th Annual Natural Supplements Conference, San Diego, California.January 22-25, 2009. 2009.
    2. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    3. Kelly GS. 'Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern.Med Rev 1999;4:96-103.
    4. Cui SW. Polysaccharide Gums from Agricultural Products: Processing, Structures & Functionality. Lancaster, Pa.: Technomic Publishing Co., Inc., 2001.
    5. Udani JK. Immunomodulatory effects of ResistAid: A randomized, double-blind, placebo-controlled, multidose study. J Am Coll Nutr 2013;32:331-8.
    6. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:1-7.
    7. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory infections. Curr Med Res Opin 2013;29:251-8.
  • Beta-1,3-glucans (from curdlan)

    Beta-1,3-glucans are large polysaccharides that can be derived from the cell walls of algae, bacteria, fungi, yeast and plants. They are considered a form of soluble fiber that are indigestible by human intestinal enzymes 1.
      Curdlan is a specific beta-1,3-glucan derived from the nonpathogenic bacterium, Alcaligenes faecalis. It is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) 2.

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.
    2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Bifidobacterium bifidum

    Bifidobacterium bifidum is a strain of lactic acid-producing bacteria normally found in the human intestine, more so in breast-fed infants than in adults. Bifidobacterium bifidum is considered a probiotic, beneficial bacteria that help maintain the health of the intestinal tract and aid in digestion. Probiotics also assist in nutrient absorption and help control the amount of harmful bacteria in the gut. Probiotics come from food sources, such as yogurt, but they can also be consumed as dietary supplements. Orally, Bifidobacterium bifidum seems to be well-tolerated by most people. No adverse effects from Bifidobacteria ingestion have been reported 1.

    Expand References

    References

    1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.
  • Black currant seed

    Black currant seed. The black currant shrub, Ribes nigrum, is native to areas in Europe and Asia. The black currant fruit, seed, bark and leaves are all used for dietary purposes 1. Black currant seeds contain high molecular weight polysaccharides and are a source of dietary fiber 2, 3.

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.
  • Borage oil (seed)

    Borage oil is derived from the seeds of the borage plant, Borago officinalis, an herb grown in the Middle East and the Mediterranean region. Borage oil is a rich source of the long-chain polyunsaturated fatty acid, gamma-linolenic acid (GLA), to which many of the health benefits of borage oil are attributed 1. Borage oil is likely safe when used orally and appropriately 2.

    Expand References

    References

    1. PDR for Nutritional Supplements. Montvale, NJ: Physicians’ Desk Reference, Inc, 2008.
  • Cellulase

    Cellulase is an enzyme produced by fungi, bacteria and other microscopic organisms. Production of cellulase by intestinal bacteria helps with the digestion of plant cellulose and other beta-glucans, which are indigestible by human enzymes 1. Cellulase derived from widely utilized fungi, such as Aspergillus niger and Trichoderma longibrachiatum, is approved for use as a food enzyme by the U.S. Food and Drug Administration (FDA) 2.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.
  • Fennel (seed)

    Fennel, Foeniculum vulgare, is an herb native to the Mediterranean region. For centuries, fennel seeds have been a valued herb in Europe and China. Today, fennel is used as a flavor component in beverages, candy, baked goods and meat products. Fennel seed is a rich source of beta-carotene and vitamin C, and also contains significant amounts of calcium, magnesium and iron 1. Fennel is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use as a natural flavoring (21CFR182.10).

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.
  • Fenugreek (seed)

    Fenugreek, Trigonella foenum-graecum, is an herb native to areas of Asia and Europe. It has a long history of use in traditional Indian and Chinese cultures. Fenugreek is commonly consumed as an ingredient in curry and many spice blends. Fenugreek seeds are also a source of dietary fiber 1. Fenugreek is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use as a spice or natural seasoning (21CFR182.10).

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.
  • Flax (seed)

    Flax (seed). Flax seeds are the seeds of the common flax, or linseed plant, Linum usitatissimum. They contain high levels of lignans, polyphenolic compounds that have been shown to be beneficial to human health. Flax seeds also contain a significant amount of protein and the essential fatty acid, alpha-linolenic acid (ALA), a biological precursor to omega-3 fatty acids such as eicosapentanoic acid (EPA) 1. Flax seed appears to be well-tolerated, and there is long-standing historical use of flax seed products in dietary supplements 2.

    Expand References

    References

    1. PDR for Nutritional Supplements. Montvale, NJ: Physicians’ Desk Reference, Inc, 2008.
  • Ghatti gum

    Ghatti gum, a mixture of complex polysaccharides, comes from the bark of Anogeissus latifolia, a large tree native to India and Sri Lanka. Monosaccharide constituents include arabinose, galactose, mannose, xylose and glucuronic acid. Ghatti gum is used in supplements, foods, drugs and cosmetics. It contains as much as 80% soluble dietary fiber 1.

    Most gums are believed to be largely degraded in the colon 2. Test tube studies have demonstrated the fermentation of ghatti gum by the beneficial human bacteria species Bifidobacterium 3,4. Ghatti gum is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and is permitted for use as a food (21CFR184.1333).

    Expand References

    References

    1. Glicksman M. Gum Ghatti (Indian gum). In: Glicksman M, ed. Food Hydrocolloids. Boca Raton: CRC Press 1983:31-7.
    2. Hill MJ. Bacterial fermentation of complex carbohydrate in the human colon. Eur J Cancer Prev 1995;4:353-8.
    3. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    4. Salyers AA, West SE, Vercellotti JR, Wilkins TD. Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon. Appl Environ Microbiol 1977;34:529-33.
  • Ginger (root)

    Ginger, Zingiber officinale, is an herb grown in a number of Asian, African and Caribbean countries. The roots and underground stems have long been used in traditional Chinese, Indian and Japanese cultures. Ginger is widely used as a food spice, especially in Oriental cooking. Dried powdered root is also used in herbal teas and supplements 1. Ginger is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use as a spice or natural seasoning (21CFR182.10).

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Leung A, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. New York, NY: John Wiley, 1996.
  • Glucomannan

    Glucomannan is a polysaccharide derived from the tuber of the konjac plant, Amorphophallus konjac. It is used as a thickening agent in foods and is marketed in the United States as a dietary supplement. Glucomannan is considered a soluble dietary fiber that is indigestible by human intestinal enzymes. It can be degraded by intestinal bacteria into short chain fatty acids, such as propionic and butyric acids 1. Glucomannan is likely safe when used orally as food 2.

    Expand References

    References

    1. PDR for Nutritional Supplements. Montvale, NJ: Physicians’ Desk Reference, Inc, 2008.
  • Gum tragacanth

    Gum tragacanth comes from the stems and branches of the flowering plant Astragalus gummifer. The raw gum is made up of a mixture of two polysaccharides. Monosaccharide constituents include galactose, arabinose, xylose, fucose, rhamnose, and galacturonic acid 1. Gum tragacanth has been approved for use in pharmaceuticals in the U.S. since 1820 and in foods since 1925 2. Most gums are believed to be largely degraded in the colon 3. Test tube studies have demonstrated that gum tragacanth can be digested by a number of bacteria that inhabit the human colon, including the beneficial Bifidobacteria species 4,5. Gum tragacanth is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and is commonly added to foods (21CFR184.1351).

    Expand References

    References

    1. Anderson DM, Howlett JF, McNab CG. The amino acid composition of the proteinaceous component of gum tragacanth (Asiatic Astragalus spp.). Food Addit Contam 1985;2:231-5.
    2. Anderson DM. Evidence for the safety of gum tragacanth (Asiatic Astragalus spp.) and modern criteria for the evaluation of food additives. Food Addit Contam 1989;6:1-12.
    3. Hill MJ. Bacterial fermentation of complex carbohydrate in the human colon. Eur J Cancer Prev 1995;4:353-8.
    4. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
    5. Salyers AA, West SE, Vercellotti JR, Wilkins TD. Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon. Appl Environ Microbiol 1977;34:529-33.
  • Inulin-oligosaccharide complex (chicory root)

    Inulin-oligosaccharide complex (chicory root). Inulin is a fructose-rich oligosaccharide that occurs naturally in plants, including a number of fruits and vegetables such as onions, leeks, garlic, bananas, asparagus and artichokes. Inulin is commonly added to foods due to its sweet taste and texture. Intake in the U.S. ranges from 1 to 4 grams daily. Inulin is considered a form of soluble fiber that is sometimes seen as a prebiotic, a non-digestible food ingredient that promotes the growth and/or activity of beneficial bacteria in the colon. Inulin-type prebiotics also include fructooligosaccharides and oligofructose 1. The U.S. Food and Drug Administration (FDA) has been notified that industry considers inulin to be generally recognized as safe (GRAS) for use in foods and has not objected to their use for this purpose (GRN No. 000118).
      Dahlia plants, such as Dahlia variabilis, are native to Mexico and Central America. They are widely cultivated for their various colorful flower heads. The fructose-containing oligosaccharide, inulin, can be obtained from the dried juice of dahlia tubers 2.
      Chicory, Cichorium intybus, is a plant native to Europe and areas of Asia. It was cultivated by ancient Egyptians, and is now consumed as a vegetable in salads in Europe and the United States. Fructans, such as inulin and oligofructose, are extracted from chicory roots 3.

    Expand References

    References

    1. PDR for Nutritional Supplements. Montvale, NJ: Physicians’ Desk Reference, Inc, 2008.
  • Lactase

    Lactase is an enzyme that breaks down lactose, a disaccharide found in milk, into the monosaccharides glucose and galactose. In humans, lactase is located on the membranes of epithelial cells lining the small intestine. Lactose intolerance is caused by the absence or deficiency of this enzyme in the intestinal system 1. Lactase derived from certain strains of yeast is approved for use as a food enzyme by the U.S. Food and Drug Administration (FDA) 2.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.
  • Lactobacillus acidophilus

    Lactobacillus acidophilus is a strain of lactic acid-producing bacteria that is naturally found in the human gastrointestinal tract. It is commonly found in fermented milk products, such as yogurt, and can also be consumed as a dietary supplement. Lactobacillus acidophilus is considered a probiotic, beneficial bacteria that help maintain the health of the intestinal tract and aid in digestion. Probiotics also assist in nutrient absorption and help control the amount of harmful bacteria in the gut. Orally, Lactobacillus species are usually well-tolerated, the most common side effect being a mild case of flatulence that tends to subside as consumption continues 1.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.
  • Lactobacillus casei

    Lactobacillus casei is a strain of lactic acid-producing bacteria normally found in the human intestine. It is considered a type of probiotic, beneficial bacteria that help maintain the health of the intestinal tract and aid in digestion. Probiotics also assist in nutrient absorption and help control the amount of harmful bacteria in the gut. Probiotics come from food sources, such as yogurt, but they can also be consumed as dietary supplements. Orally, Lactobacillus species are usually well-tolerated, the most common side effect being a mild case of flatulence that tends to subside as consumption continues 1.

    Expand References

    References

    1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.
  • Lactobacillus plantarum

    Lactobacillus plantarum is a strain of lactic acid-producing bacteria that is naturally found in the human gastrointestinal tract. It is commonly found in fermented food products and can be consumed as a probiotic dietary supplement. Probiotics are beneficial bacteria that help maintain the health of the intestinal tract and aid in digestion. They also assist in nutrient absorption and help control the amount of harmful bacteria in the gut. Orally, Lactobacillus species are usually well-tolerated, the most common side effect being a mild case of flatulence that tends to subside as consumption continues 1.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.
  • Lactobacillus sporogenes

    Lactobacillus sporogenes, also referred to as Bacillus coagulans, is a strain of lactic acid-producing bacteria used as a probiotic in foods and dietary supplements. Probiotics are beneficial bacteria that help maintain the health of the intestinal tract and aid in digestion. They also assist in nutrient absorption and help control the amount of harmful bacteria in the gut. Orally, Lactobacillus species are usually well-tolerated, the most common side effect being a mild case of flatulence that tends to subside as consumption continues 1.

    Expand References

    References

    1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.
  • Lipase

    Lipase is an enzyme that digests fat-soluble molecules called lipids. It is found in many plants, milk, dairy products, bacteria, molds and animal tissues. In the human digestive system, lipase is made by the pancreas and secreted into the intestines to help break down dietary fats 1. Lipase derived from animal tissue and certain nontoxic and nonpathogenic fungi is approved for use as a food enzyme by the U.S. Food and Drug Administration (FDA) 2.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.
    2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Oat fiber

    Oat fiber. Oats contain a large amount of soluble fiber, consisting of polysaccharides called beta-glucans. Consumption of oat beta-glucans has beneficial effects on human health 1. They are approved for use as a source of dietary fiber by the U.S. Food and Drug Administration (FDA) (21CFR101.81).

    Expand References

    References

    1. PDR for Nutritional Supplements. Montvale, NJ: Physicians’ Desk Reference, Inc, 2008.
  • Orange (flower)

    Orange (flower). The bitter orange tree, Citrus aurantium, is a flowering, citrus fruit-bearing tree native to tropical Asia. Over the centuries, bitter orange has been highly valued as a food and for its health benefits. The bitter orange peel, flowers and leaves contain flavonoids that have antioxidant activities 1. The flowers of Citrus aurantium are considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use as food additives (21CFR182.20) 2.

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.
    2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Protease

    Proteases are protein-digesting enzymes. While they occur naturally in all organisms, proteases in supplements are typically obtained from safe, non-pathogenic fungi. Orally administered protein-digesting enzymes can be detected in human blood, at least to some extent, in their intact, biologically active form 1.

    Expand References

    References

    1. Kolac C, Streichhan P, Lehr C-M. Oral bioavailability of proteolytic enzymes. Eur J Pharmacol Biopharm 1996;42:222-32.
  • Psyllium (seed husk)

    Psyllium (seed husk) is a mixture of polysaccharides derived from the husks of the seeds of Plantago plant species. It has a high level of soluble dietary fiber. Psyllium is used in processed foods, such as cereals, and in various dietary supplement formulations to increase fiber intake. It passes through the gastrointestinal tract largely unchanged 1. Psyllium seed husk is approved for use as a source of dietary fiber by the U.S. Food and Drug Administration (FDA) (21CFR101.81) 2.

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.
  • Rice bran (hull)

    Rice bran hulls are the outer layer of the rice seed. Rice hulls consist mainly of plant fibers (lignin, hemicellulose, cellulose) and hydrated silica. They also contain a small amount of protein and fat 1 .

    Expand References

    References

    1. Friedman, M. Rice brans, rice bran oils, and rice hulls: composition, food and industrial uses, and bioactivities in humans, animals, and cells. J Agric Food Chem 2013; 61(45): 10626-41.
  • Rosemary (leaf)

    Rosemary, Rosmarinus officinalis, is a small evergreen shrub grown in many parts of the world. The fresh and dried leaves are used as flavoring agents and food preservatives. Rosemary has been used for centuries as a valued herb. It contains a number of phytochemicals that demonstrate antioxidant activity, including caffeic, carnosic and rosmarinic acids 1. Rosemary is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use as a spice or natural seasoning (21CFR182.10).

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.

Formulation

  • Carrageenan

    Carrageenan is a sulfated polysaccharide extracted from species of red algae, including Gigartina skottsbergii, Chondrus crispus and Eucheuma cottonii. The solubility and gelling capability of carrageenans differ depending on the type of red algae used. Carrageenan has been used for hundreds of years as a food additive. In foods, it acts as a thickener and stabilizer 1. Carrageenan is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) 2.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Natural Standard Database. www.naturalstandard.com. 2009.
  • Croscarmellose sodium

    Croscarmellose sodium, the sodium salt of a cellulose, is added to capsules, tablets and granules to help them disintegrate following ingestion. Croscarmellose sodium is generally regarded as an essentially nontoxic material. Consumption of large quantities may have a laxative effect, although the quantities used in capsules or tablets are unlikely to cause this problem 1.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Gurnee, IL: Pharmaceutical Press, 2006.
  • Dicalcium phosphate dihydrate

    Dicalcium phosphate dihydrate (calcium phosphate, dibasic) is a white, odorless, tasteless powder used both as an excipient and as a source of calcium and phosphorous in dietary supplements. It is widely used in the nutritional and health food sectors 1. Calcium phosphate, dibasic is an approved food additive by the U.S. Food and Drug Administration (FDA) 2.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
  • Hydroxypropyl cellulose

    Hydroxypropyl cellulose (HPC) is a derivative of cellulose that is water-soluble. HPC is used in food products as a thickener and to stabilize oil-in-water mixtures. It is also used in oral formulations (i.e. capsules and tablets) as a binder and to assist in disintegration 1. Hydroxypropyl cellulose is an approved food additive by the U.S. Food and Drug Administration (FDA) 2, by the Natural Products Health Directorate in Canada (http://www.hc-sc.gc.ca) and by the European Food Safety Authority (http://eur-lex.europa.eu).

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
  • Hypromellose

    Hypromellose, also known as hydroxypropyl methylcellulose (HPMC), is a derivative of cellulose. In oral products, hypromellose is primarily used as a binder and for encapsulation as an alternative to animal-derived gelatin. In foods, it is used as a thickener and to stabilize oil-in-water mixtures 1. Hypromellose is an approved food additive by the U.S. Food and Drug Administration (FDA) 2.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
    2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
  • Magnesium stearate

    Magnesium stearate, a salt of stearic acid, is widely used in cosmetics, foods, and capsules as a lubricating agent. In dietary supplements it may contain a mixture of magnesium salts of different fatty acids. 
      Magnesium stearate is approved by the U.S. Food and Drug Administration (FDA) as generally recognized as safe (GRAS) (21CFR184.1440) and is generally regarded as being nontoxic following oral administration. Oral consumption of large quantities may produce a laxative effect or cause mucosal irritation 1.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Gurnee, IL: Pharmaceutical Press, 2006.
  • Microcrystalline cellulose

    Microcrystalline cellulose (MC) is a purified plant fiber that is widely used in food products and in dietary supplement tablets to: 1) bind ingredients together, or 2) help the tablet disintegrate properly.

    Following ingestion, MC is not absorbed by the human body. Because it is not absorbed, it has little potential for toxicity. Consumption of large quantities of cellulose may have a laxative effect, but this is unlikely to be a problem for individuals consuming the small amounts included in dietary supplement tablets 1.

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
  • Natural flavor(s)

    Natural flavors are oils or extracts containing the flavoring constituents derived from a variety of sources. The natural flavors in Mannatech’s products may be derived from spices, fruits or fruit juices, vegetables or vegetable juices, herbs, bark, buds, roots, leaves or similar plant materials, or dairy products. The significant function of such ingredients in foods or supplements is for flavor rather than nutrition (21CFR501.22).

  • Silicon dioxide

    Silicon dioxide, also known as silica, is added to capsule and tablet formulations to reduce clumping 1. Silica is found in many foods, particularly whole grains (oats and barley), sugar beets, sugar cane, soybeans, turnips, green beans 2. The average intake of silica in adults is 14-21 mg/day 3. The bioavailability of silicate additives is low 4. Silica that occurs in food and water has not been shown to cause any adverse effects 3.

    Expand References

    References

    1. The Merck Index. Whitehouse Station, NJ: Merck & Co., 2006.
    2. Nutritional Biochemistry and Metabolism. New York, New York: Elsevier, 1991.
    3. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.
    4. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, D.C.: National Academy Press, 2002.
  • Sodium caprylate

    Sodium caprylate is the sodium salt of caprylic acid, a medium chain fatty acid. Medium chain fatty acids are found in medium chain triglycerides, which are sometimes used as nutritional agents 1. Sodium caprylate is typically used in foods as a binder, to aid in the mixing of ingredients and to prevent caking. Sodium caprylate is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) (21CFR172.863) 2.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
  • Soy lecithin

    Soy lecithin is a combination of naturally occurring phospholipids extracted during the processing of soybean oil. It consists of three types of phospholipids- phosphatidylcholine, phosphatidylethanolamine and phosphotidylinositol. Soy lecithin is used commercially in substances as a natural way to stabilize liquid mixtures. Lecithin is approved by the U.S. Food and Drug Administration (FDA) for human consumption with the status generally recognized as safe (GRAS) (21CFR184.1400).

  • Stearic acid

    Stearic acid is a naturally occurring fatty acid that is found in animal and vegetable fats. In dietary supplements, it is typically a combination of stearic and palmitic acids. Stearic acid is used as a lubricantin capsules and tablets and is also used widely in cosmetics and food products 1. It is used in topical formulations to assist in mixing ingredients and to stabilize oil-in-water mixtures 2.

    Stearic acid is approved by the U.S. Food and Drug Administration (FDA) as generally recognized as safe (GRAS) (21CFR184.1090) and is generally regarded as a nontoxic and nonirritating material 1. It is also included in the U.S. FDA Inactive Ingredients Guide as safe to use in the amounts present in our products 3.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Gurnee, IL: Pharmaceutical Press, 2006.
    2. International Cosmetic Ingredient Dictionary and Handbook. Washington, D.C.: The Cosmetic, Toiletry and Fragrance Association, 2006.
    3. FDA Inactive Ingredients Guide. http://www.accessdata.fda.gov/scripts/cder/iig/index.cfm. 2007.

Product Claims

Products

MannaCLEANSE™ Caplets

Product Numbers

36101: 120 MannaCLEANSE Caplets

Country

South Africa

Effective

September 2016

Supersedes

December 2014
  • Quality and Safety
    • Naturally gluten-free
    • Gluten-free
    • Suitable for vegetarians
    • Free from preservatives and artificial colors
  • Benefits

    4/Day MannaCLEANSE Caplets


     

    • Digestive support supplement*
    • Designed to help support the body’s lower digestive tract by supporting the natural ecology of the intestines*
    • Designed to promote proper colon ecology and function*
    • Each ingredient in MannaCLEANSE has been carefully selected to support the natural health of the intestinal tract*
    • This formula combines ingredients that are designed to provide a healthy environment for the intestinal tract:*
      • Fiber blend [black currant seed, flax seed, psyllium seed husk, oat fiber];
      • Prebiotics [glucans, glucomannans];
      • Botanical blend [fennel seed, fenugreek seed powder, ginger root, peppermint leaf, rosemary leaf, orange flower];
      • Fatty acid source blend [flax seed, rice bran, soy lecithin, borage seed];
      • Enzyme blend [amylase, cellulose, lactase, lipase, protease];
      • Gut flora growth promotants (prebiotics) [inulin-oligosaccharide complex from dried juice Dahlia variabilis tuber and chicory root, beta-glucan];
      • Probiotic flora [Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Lactobacillus sporogenes, Bifidobacteria bifidum]; and
      • Glyconutrients/polysaccharides [Ambrotose® complex, beta-glucan, chicory root, glucomannans]
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